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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in grown-ups with a body mass index (BMI) of greater than 27, so long as they also are afflicted by weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure levels).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to quitting smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that features a reduced-calorie diet and exercise, Contrave provides another treatment selection for chronic weight management for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a clinical study that enrolled patients without diabetes showed that patients had the average weight loss of four.1% instead of participants who were given placebos) throughout a 12- month period, while another study involving patients with diabetes type 2 symptoms had an average weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to lose weight naturally can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you need to err assisting caution and allow the FDA do its job and demand some research be done so that the public is aware of the side effects and risks of the medications before we bring them. Keep in mind that drug companies come in business to earn money and that they would say everything to keep people on his or her medications.

Researchers found out that participants using this drug to get a year, dropped excess weight within four weeks and have kept the extra weight off through the 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which can be made up of multiple active ingredient, which may make them far better and safer.

Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is now popular may be the fact that since right now there are not any long term prescription slimming capsules that have been authorized by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in people with seizure disorders. The drug can also raise blood pressure and heart rate, and mustn't be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must not be used in patients with uncontrolled high hypertension, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.

From a psychiatric perspective, evidence shows that the ordinary neural mechanism for goal-directed behavior continues to be hijacked through the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object generates a stimulus along with the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).

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